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The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). You will need to discuss the benefits and risks of using Allopurinol  while you are pregnant. However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol.

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